GABA-T in bovine medulla cells: kinetic properties and comparison with GABA-T from other tissues

4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T) has been found in adrenal medulla. The enzyme from this tissue is very similar to those found in other tissues in respect to their mitochondrial localization, optima pH and responses to cofactor. The enzyme from medulla has substrate km values similar to those for the brain enzyme, while it differs from those found for other tissues such as kidney, liver and platelets.