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[Food hypersensitivity in infants].

M Martín Esteban, C Pascual Marcos, M C García Ara

    Anales Espanoles De Pediatria
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Infant food hypersensitivity, often IgE-mediated, can occur without prior food exposure. Breast milk may play a role in sensitization, even with minimal antigen exposure.

    Area of Science:

    • Allergy and Immunology
    • Pediatrics
    • Immunology

    Context:

    • Investigates immediate, immunoglobulin E (IgE)-mediated food hypersensitivity in infants.
    • Examines the relationship between food intake, sensitization, and clinical symptoms.
    • Compares breastfeeding prevalence in sensitized infants versus a control group.

    Purpose:

    • To determine the frequency and characteristics of food hypersensitivity in infants.
    • To explore potential sensitization pathways, including breastfeeding and transplacental antigen passage.
    • To understand the role of antigen quantity and genetic predisposition in IgE-mediated food hypersensitivity.

    Summary:

    • Food hypersensitivity in infants is frequently IgE-mediated and can manifest without prior antigen ingestion.

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  • A significant proportion of infants (80%) showed elevated total serum IgE levels.
  • Symptoms appeared upon first food intake or sensitization occurred before ingestion in 26 cases, predominantly in breastfed infants.
  • Breastfeeding prevalence was significantly higher in the hypersensitive group compared to controls (p < 0.001).
  • Food hypersensitivity does not always result in clinical intolerance, suggesting complex immune responses.

    • Impact:

    • Suggests that sensitization can occur through breast milk or transplacental antigen transfer.
    • Highlights the potential for sensitization by minute antigen quantities in genetically predisposed infants.
    • Informs understanding of early-life allergy development and potential preventative strategies.