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Related Experiment Videos

Electrocardiogram and His bundle electrogram of Japanese monkeys (Macaca fuscata).

S Imanishi, M Arita, M Aomine

    Jikken Dobutsu. Experimental Animals
    |October 1, 1983
    PubMed
    Summary

    Electrocardiogram (ECG) and His bundle electrogram (HBE) in Macaca fuscata show patterns similar to humans but with shorter intervals, likely due to smaller heart size. These findings establish a reference for Macaca fuscata as a model for human ECG studies.

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    Area of Science:

    • Cardiology
    • Comparative Physiology
    • Animal Models

    Background:

    • Electrocardiography (ECG) and His bundle electrogram (HBE) are crucial diagnostic tools in human cardiology.
    • Understanding cardiac electrophysiology in non-human primates can provide valuable insights into human cardiovascular function.

    Purpose of the Study:

    • To characterize the standard electrocardiogram (ECG) and His bundle electrogram (HBE) in anesthetized Macaca fuscata.
    • To establish reference values for ECG and HBE parameters in Macaca fuscata.
    • To evaluate the utility of Macaca fuscata as an animal model for studying human cardiac electrophysiology, particularly repolarization.

    Main Methods:

    • Standard 12-lead ECG and augmented unipolar limb leads were recorded from Macaca fuscata under secobarbital anesthesia.

    Related Experiment Videos

  • His bundle electrograms (HBE) were obtained using a tripolar electrode catheter inserted via the femoral vein.
  • Key intervals including PR, QRS, QT, P wave duration, and HBE intervals (PA, AH, HV, PV) were measured.

    • Main Results:

    • Macaca fuscata ECG exhibited general patterns and wave voltages comparable to humans and other monkey species, with a notably different heart rate.
    • The T wave direction in Macaca fuscata ECG was consistent with human ECG.
    • Measured ECG and HBE intervals in Macaca fuscata were approximately 50% of human values, potentially attributed to smaller heart size.

    Conclusions:

    • The recorded ECG and HBE measurements provide a normal reference for Macaca fuscata under anesthesia.
    • Macaca fuscata demonstrates potential as a valuable animal model for investigating human ECG repolarization processes.
    • The study highlights significant differences in cardiac electrophysiological interval durations between Macaca fuscata and humans.