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Related Experiment Videos

Necrotizing enterocolitis--a 5-year experience.

B M Mogilner, A Shanon

    Israel Journal of Medical Sciences
    |November 1, 1983
    PubMed
    Summary
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    Necrotizing enterocolitis (NEC) is a severe condition in premature infants. This study found a 50% mortality rate, with infection strongly linked to fatal outcomes in very-low-birth-weight neonates.

    Area of Science:

    • Neonatal Intensive Care
    • Pediatric Gastroenterology
    • Infectious Diseases

    Background:

    • Necrotizing enterocolitis (NEC) is a major cause of mortality in very-low-birth-weight neonates.
    • Increased survival rates of premature infants have led to a higher incidence of NEC.
    • Understanding NEC's etiology and risk factors is crucial for improving outcomes.

    Purpose of the Study:

    • To analyze the clinical characteristics and outcomes of necrotizing enterocolitis (NEC) in very-low-birth-weight neonates.
    • To investigate the role of infectious agents in the development and mortality of NEC.
    • To evaluate the effectiveness of prophylactic oral kanamycin in preventing NEC.

    Main Methods:

    • Retrospective analysis of 24 confirmed NEC cases over a 5-year period (1977-1981).

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  • Data collected included infant weight, gestational age, age at onset, feeding status, and microbiological cultures.
  • Correlation of positive cultures (bacterial, viral) with clinical outcomes and mortality.

    • Main Results:

    • The mean birth weight was 1,450 g, mean gestational age 32 weeks; most affected infants were premature.
    • Infectious agents, primarily gram-negative rods, were isolated from critically ill infants.
    • Positive blood and gastric aspirate cultures were found in 10 of 12 fatal cases; no bacteria were isolated from survivors' blood.
    • Prophylactic oral kanamycin showed no preventive effect on NEC incidence.
    • Overall mortality was 50%, with no long-term sequelae in survivors.

    Conclusions:

    • Overwhelming infection appears to play a significant role in the high mortality associated with NEC in this cohort.
    • Early identification and management of infectious agents are critical for improving survival rates.
    • Further research is needed to elucidate NEC pathogenesis and develop effective preventive strategies.