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Related Experiment Videos

Prognostic index in malignant melanoma.

C Schmoeckel, O Braun-Falco

    Archives of Dermatology
    |June 1, 1978
    PubMed
    Summary

    The prognostic index, a product of tumor thickness and mitotic rate, effectively identifies melanoma patients needing further treatment. Mitotic rate alone is also a strong predictor for metastasis-free survival in early-stage melanoma.

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    The American Journal of dermatopathology·1996

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Primary cutaneous melanoma is a significant public health concern.
    • Accurate prognostication is crucial for effective patient management and treatment selection.
    • Identifying reliable prognostic factors aids in stratifying patients with early-stage melanoma.

    Purpose of the Study:

    • To identify prognostic factors for predicting outcomes in surgically treated primary cutaneous melanoma.
    • To evaluate the efficacy of the prognostic index (tumor thickness × mitotic rate) and its components.
    • To determine the best method for identifying patients with poor prognoses and those with no risk of metastasis.

    Main Methods:

    • Retrospective analysis of 146 surgically treated primary cutaneous melanoma cases.
    • Comparison of tumor thickness, mitotic rate, and a combined prognostic index.
    • Evaluation of disease-free status and development of metastases over time.

    Main Results:

    • The prognostic index (tumor thickness × mitotic rate) was the best overall predictor of prognosis.
    • Mitotic rate alone was as effective as the prognostic index for identifying metastasis-free patients.
    • Mitotic rate outperformed tumor thickness and invasion levels in predicting metastasis-free survival.

    Conclusions:

    • The prognostic index is valuable for selecting stage I melanoma patients who may benefit from further treatment.
    • Prophylactic interventions such as lymph node dissection and immunochemotherapy can be considered for high-risk patients.
    • Mitotic rate is a key factor in predicting melanoma metastasis and guiding treatment decisions.

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