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Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
Published on: January 22, 2018
Summary
Retinal pigment epithelial tears are a recent complication of detachments. These tears, often spontaneous or post-laser, lead to poor visual prognosis, especially when affecting the subfoveal area.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vitreoretinal Surgery
Background:
- Retinal pigment epithelial tears are a recently identified complication.
- They occur at the margin of retinal pigment epithelial detachments.
- These tears involve the separation of retinal pigment epithelium layers.
Purpose of the Study:
- To describe the characteristics of retinal pigment epithelial tears.
- To identify potential causes and associated factors.
- To evaluate the visual prognosis associated with these tears.
Main Methods:
- Observational case reviews.
- Clinical examination of patients with retinal pigment epithelial tears.
- Analysis of medical history, including laser photocoagulation procedures.
Main Results:
- Retinal pigment epithelial tears present as sudden separations at the detachment margin.
- Retraction of the pigment epithelium exposes underlying Bruch's membrane and choroid.
- Tears can arise spontaneously or after krypton red laser photocoagulation.
- Subfoveolar involvement is associated with a poor visual prognosis.
Conclusions:
- Retinal pigment epithelial tears are a significant complication of detachments.
- Spontaneous occurrence and post-laser complications are noted.
- Early recognition and understanding of tear location are crucial for predicting visual outcomes.
