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Blepharospasm associated with brainstem lesions.

J Jankovic, S C Patel

    Neurology
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Rostral brainstem lesions, often from strokes or multiple sclerosis, can cause bilateral blepharospasm. Treatment options include medication and, in some cases, facial nerve surgery.

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    Area of Science:

    • Neurology
    • Neuroscience
    • Ophthalmology

    Background:

    • Bilateral blepharospasm is a focal dystonia affecting the muscles around the eyes.
    • Rostral brainstem lesions are implicated in various neurological disorders.

    Observation:

    • Six patients with clinical and radiographic evidence of rostral brainstem lesions and bilateral blepharospasm were studied.
    • Two patients also exhibited other facial dystonic movements.
    • Etiologies included four cases of rostral brainstem stroke and two cases of multiple sclerosis.

    Findings:

    • None of the patients had prior treatment with antipsychotic drugs.
    • Medical treatments provided benefit in two patients.
    • One patient underwent successful bilateral selective facial nerve section.

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    Implications:

    • This study highlights the rostral brainstem as a potential site for lesions causing blepharospasm.
    • Understanding pathogenic mechanisms is crucial for developing targeted therapies.
    • Facial nerve surgery may be a viable option for refractory blepharospasm in these cases.