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Summary
Pulmonary infiltrates, a serious side effect, can develop in patients taking the antiarrhythmic drug amiodarone. Radiologists should monitor for early lung changes in patients with amiodarone therapy history.
Area of Science:
- Cardiology
- Pulmonology
- Radiology
Background:
- Amiodarone (Cordarone) is an antiarrhythmic medication used for cardiac arrhythmias.
- Its evaluation in the United States has revealed potential adverse effects.
Purpose of the Study:
- To report the occurrence of pulmonary infiltrates in patients treated with amiodarone.
- To alert radiologists to a potential serious side effect of amiodarone therapy.
Main Methods:
- Observational study of 34 patients receiving amiodarone.
- Dosage: 200-800 mg daily.
- Duration: 1.5 to 12 months.
Main Results:
- Six out of 34 patients (17.6%) developed pulmonary infiltrates.
- Two patients died, one recovered after discontinuation, and three had residual abnormalities.
- Two patients with residual abnormalities continued amiodarone with steroids.
Conclusions:
- Amiodarone therapy can lead to serious pulmonary complications.
- Early detection by radiologists is crucial for managing amiodarone-induced lung injury.