Effect of meptazinol and ethanol on human psychomotor performance and mood ratings

The effect of meptazinol and/or ethanol on human psychomotor performance and mood ratings has been investigated in 8 healthy volunteers in a double blind randomised study. Meptazinol (200 mg 3 hourly for 4 doses) or placebo were administered orally and ethanol (0.8 g/kg) or placebo were given 30 min after the last tablet. Peak saccadic velocity (PSV), saccade duration at 30 degrees of amplitude (SD), smooth pursuit velocity (SPV), critical flicker fusion threshold (CFF), choice reaction time (CRT) and visual analogue scales were assessed. PSV (p less than 0.01), SD (p less than 0.001) and SPV (p less than 0.01) were significantly impaired after ethanol, while CFF, CFT and visual analogue scales showed no significant effect. None of the tests was affected by the meptazinol treatment alone. No changes were observed in the ethanol-induced impairment of PSV, SD and SPV when meptazinol was given in combination with ethanol.