HLA haplotype segregation study in multiple case families of pulmonary tuberculosis

Twenty-five multiple case families of pulmonary tuberculosis were HLA typed and the data analysed by the lod score method. There was no evidence of linkage between the susceptibility gene and pulmonary TB, though there were consistently positive female scores. A number of other chromosome 6 genetic markers tested did not reveal any significant deviation in the patient group as compared to the controls, except GLO 2-1 which occurred with a significantly decreased frequency in the former.