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Basophils in peripheral blood and bone marrow. A retrospective review
Abstract:
The records on 375 consecutive bone marrow aspirations were reviewed to establish the incidence and association of peripheral and bone marrow basophilia. Seventeen cases of peripheral basophilia were identified (4.5 percent incidence) and were associated with iron deficiency (five cases), lung carcinoma (four cases), anemia of undetermined cause (four cases), and chronic myelogenous leukemia, myelodysplasia, chronic renal failure, and acute myelogenous leukemia (one case each). There were six cases of marrow basophilia, including iron-deficiency anemia (two cases), sideroblastic anemia with myelodysplasia, mild dyspoiesis, anemia of chronic disease, and acute erythroleukemia. Marrow basophilia was significantly associated with myelodysplasia and sideroblastic anemia, but was not found in 37 patients with lymphoproliferative disorders. There were no instances of simultaneous marrow and peripheral basophilia. These data support the concept that marrow basophilia is a specific, although not sensitive, marker of disruption of the normal marrow maturation controls.
Insights
Peripheral and bone marrow basophilia are uncommon, with no simultaneous occurrences. Bone marrow basophilia may indicate disrupted marrow maturation, particularly in myelodysplasia and sideroblastic anemia.
Area of Science:
- Hematology
- Oncology
Background:
- Basophilia, an increase in basophils, can manifest in peripheral blood or bone marrow.
- Understanding the incidence and associations of basophilia is crucial for diagnosing hematologic disorders.
Purpose of the Study:
- To determine the incidence of peripheral and bone marrow basophilia.
- To investigate the associations between basophilia and various medical conditions.
Main Methods:
- Retrospective review of 375 bone marrow aspiration records.
- Analysis of peripheral blood and bone marrow findings.
Main Results:
- Peripheral basophilia occurred in 4.5% of cases, associated with iron deficiency, lung carcinoma, and various anemias.
- Bone marrow basophilia was less common and linked to myelodysplasia and sideroblastic anemia.
- No cases showed simultaneous peripheral and bone marrow basophilia.
Conclusions:
- Bone marrow basophilia is a specific, though not highly sensitive, marker for disrupted bone marrow maturation controls.
- Peripheral basophilia has diverse associations, while marrow basophilia is more specifically linked to myelodysplastic syndromes.