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Related Experiment Videos

Chrysosporium, a new causative agent in osteomyelitis. A case report.

W T Stillwell, B D Rubin, J L Axelrod

    Clinical Orthopaedics and Related Research
    |April 1, 1984
    PubMed
    Summary

    This case study highlights Chrysosporium as a rare cause of bone infection in humans. Amphotericin B successfully treated the tibial osteomyelitis, demonstrating the fungus

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    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Orthopedic Surgery

    Background:

    • Osteomyelitis is a serious bone infection.
    • Fungal osteomyelitis is uncommon, especially in immunocompetent individuals.
    • Chrysosporium species are typically considered environmental contaminants.

    Observation:

    • A 24-year-old man presented with a two-month history of right ankle swelling and pain.
    • Radiographs revealed a progressively enlarging lucency in the distal tibia.
    • Bone scan confirmed extensive tibial lesion.
    • Biopsy showed fungal elements consistent with Chrysosporium.

    Findings:

    • Histopathology revealed histiocytic giant cells with budding yeasts and septate mycelia.
    • Chrysosporium was isolated from cultures of the tibial abscess.

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  • Treatment with Amphotericin B resulted in clinical healing within four months.
  • The patient's infection resolved with conservative management (short-leg cast).

    • Implications:

    • This case suggests Chrysosporium can be a pathogen causing invasive bone infections.
    • Early diagnosis and appropriate antifungal therapy are crucial for successful outcomes.
    • Further research is needed to understand the pathogenic potential of Chrysosporium in humans.