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[Metabolic changes in blood cells in various forms of ischemic heart disease]

V I Shepotinovskiĭ, Z I Mikashinovich

    Voprosy Meditsinskoi Khimii
    |January 1, 1984
    PubMed

    Insights

    Enzymatic activity in leukocytes and erythrocytes is altered in heart ischemic disease, impacting cellular function and blood properties. Measuring these changes aids in diagnosing various types of ischemic heart conditions.

    Area of Science:

    • Biochemistry
    • Hematology
    • Cardiology

    Context:

    • Heart ischemic disease encompasses conditions like stenocardia and myocardial infarction.
    • Leukocytes and erythrocytes exhibit metabolic alterations in patients with ischemic heart disease.

    Purpose:

    • To investigate alterations in enzymatic activity within leukocytes and erythrocytes in various clinical types of heart ischemic disease.
    • To correlate these metabolic changes with disease severity and cellular functions.

    Summary:

    • Distinct alterations in glycolysis and Krebs cycle enzyme activity were observed in leukocytes, particularly in large-scale myocardial infarction.
    • Functional impairments in leukocytes, cellular immunity, and altered hydrolytic enzyme activity contribute to energy metabolism changes.
    • Erythrocytes show altered gas transport functions and increased pentose-phosphate shunt activity, affecting blood rheology.

    Impact:

    • Enzymatic activity estimation in blood cells is crucial for diagnosing different types of heart ischemic disease.
    • Understanding these metabolic shifts provides insights into disease pathophysiology and potential diagnostic markers.

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