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[Stool behavior following the administration of antacids]
Fortschritte Der Medizin
|March 22, 1984
Summary
High magnesium antacids can cause diarrhea in ulcer patients. A triple combination antacid (Al, Mg, Ca) demonstrated neutral effects on stool consistency and frequency, making it a preferred choice.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Magnesium-containing antacids are frequently used for acid reflux and ulcer management.
- Literature suggests a correlation between magnesium dosage and gastrointestinal side effects like diarrhea.
Purpose of the Study:
- To confirm the correlation between magnesium dosage in antacids and diarrhea in ulcer patients.
- To evaluate the effects of different antacid formulations on stool consistency and frequency.
Main Methods:
- Four antacid formulations were tested: Antacid A (high magnesium), Solugastril gel, an Al-Ca antacid, and a triple combination (Al, Mg, Ca).
- A clinically relevant dosage of 420 mval NK/day was administered in six divided doses.
- Stool frequency, consistency, and serum electrolytes were monitored.
Main Results:
- 32% of participants experienced diarrhea with Antacid A (high magnesium) between days 2-4.
- Al-Ca antacids caused mild fecal impaction but increased stool frequency.
- The triple combination antacid (Al, Mg, Ca) showed neutral effects on stool parameters.
Conclusions:
- High magnesium antacids can induce diarrhea in ulcer patients.
- The triple combination antacid (Al, Mg, Ca) is recommended for its neutral effect on bowel habits.
- Monitoring serum electrolytes is crucial, especially with high-magnesium formulations.