A simple-time-series approach for evaluating an ocular plethysmograph

A simple-time-series approach for testing the efficacy of an ocular plethysmograph has been developed. This statistical methodology is used to demonstrate the clinical potential of the Buffington ocular plethysmograph for the noninvasive detection of cerebral ischemia. This is done by correlating intraocular pulse amplitude to systemic blood pressure changes during controlled hypotension induced by the intravenous administration of sodium pentobarbital (25 mg/kg) in five dogs.