Trazodone-digoxin interaction in an animal model

Serum digoxin concentrations have been reported to increase in two patients taking daily doses of trazodone. However, in a canine model, no elevation in serum digoxin concentration was found with combined trazodone-digoxin administration. The authors suggest that serum digoxin concentrations should be monitored in patients receiving trazodone and digoxin concomitantly.