Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trazodone-digoxin interaction in an animal model.

G W Dec, M A Jenike, T A Stern

    Journal of Clinical Psychopharmacology
    |June 1, 1984
    PubMed
    Summary

    Serum digoxin levels may increase when taking trazodone, but canine studies show no effect. Monitor digoxin levels in patients on both trazodone and digoxin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A seismic reflection image for the base of a tectonic plate.

    Nature·2015
    Same author

    Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1.

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2013
    Same author

    Genome-wide association study of obsessive-compulsive disorder.

    Molecular psychiatry·2012
    Same author

    A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy.

    CNS spectrums·2006
    Same author

    Apoptosis in heart failure: a tale of heightened expectations, unfulfilled promises and broken hearts em leader.

    Apoptosis : an international journal on programmed cell death·2003
    Same author

    Improvement in severe self-mutilation following limbic leucotomy: a series of 5 consecutive cases.

    The Journal of clinical psychiatry·2002

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy

    Background:

    • Trazodone is an antidepressant medication.
    • Digoxin is a cardiac glycoside used to treat heart conditions.
    • Potential drug interactions between trazodone and digoxin require investigation.

    Purpose of the Study:

    • To investigate the effect of trazodone on serum digoxin concentrations.
    • To determine if concomitant administration of trazodone and digoxin alters digoxin levels.

    Main Methods:

    • Case reports of two patients experiencing increased digoxin levels while on trazodone.
    • A canine study involving combined trazodone and digoxin administration.

    Main Results:

    • Two patients showed elevated serum digoxin concentrations with concurrent trazodone use.
    • Canine model demonstrated no significant change in serum digoxin concentration with combined administration.

    Conclusions:

    • Concomitant use of trazodone and digoxin may warrant monitoring of serum digoxin concentrations in patients.
    • Further research may be needed to clarify the interaction in humans.

    Related Experiment Videos