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Updated: Aug 26, 2026

Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport
Published on: June 28, 2014
Fine structure of tight junctions between rat choroidal cells after osmotic opening induced by urea and sucrose
Abstract:
After ventriculo-cisternal perfusion of hypertonic urea or sucrose, both the choroid plexus permeability to horseradish peroxidase and the structure of tight junctions between choroidal cells are modified. Intercellular spaces are swollen, continuous ridges are fragmented and intrajunctional spaces are invested by many membranous particles. These morphological alterations appear to be reversible. These ultrastructural data are related to an osmotic maladjustment induced by the introduction of hypertonic solutions into the cerebro-spinal fluid.
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