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High-density lipoprotein cholesterol: methods and clinical significance
Critical Reviews in Clinical Laboratory Sciences
|January 1, 1982
Summary
This review covers methods for measuring high-density lipoprotein (HDL) cholesterol, its link to heart disease risk, and factors influencing HDL levels. It suggests a practical approach for managing low HDL cholesterol.
Area of Science:
- Clinical Medicine
- Cardiovascular Disease Research
- Biochemistry
Background:
- Serum high-density lipoprotein (HDL) cholesterol is a key lipid parameter.
- Understanding HDL cholesterol measurement and its clinical significance is crucial for cardiovascular risk assessment.
Purpose of the Study:
- To review methods for determining HDL cholesterol concentration.
- To discuss the relevance of HDL cholesterol and its subfractions to ischemic heart disease.
- To explore factors affecting HDL cholesterol and propose management strategies for low levels.
Main Methods:
- Literature review of analytical methods for HDL cholesterol.
- Evidence synthesis on the association between HDL cholesterol and ischemic heart disease.
- Discussion of lifestyle and pathological factors influencing HDL cholesterol.
Main Results:
- Various methods exist for HDL cholesterol determination, each with specific clinical applicability.
- Evidence for and against HDL cholesterol as a predictor of ischemic heart disease is presented.
- Factors like diet, weight, exercise, smoking, alcohol, and hyperlipoproteinemia impact HDL cholesterol levels.
Conclusions:
- HDL cholesterol measurement methods have distinct advantages and limitations for clinical use.
- The role of HDL cholesterol and its subfractions in ischemic heart disease requires further investigation.
- A practical approach for patients with low HDL cholesterol is outlined, considering lifestyle modifications.