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Related Experiment Videos

Does insulin removal rate from plasma decline with age?

G M Reaven, M S Greenfield, C E Mondon

    Diabetes
    |August 1, 1982
    PubMed
    Summary

    Aging reduces the body's ability to clear insulin from the blood. Older rats and humans showed slower insulin removal, indicating decreased insulin catabolism with age.

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    Area of Science:

    • Endocrinology
    • Metabolism
    • Aging Research

    Background:

    • Insulin is a key hormone regulating blood glucose.
    • Understanding insulin clearance is crucial for metabolic health.
    • Age-related changes in hormone metabolism are not fully understood.

    Purpose of the Study:

    • To investigate the impact of aging on the rate of insulin removal from plasma in rats and humans.
    • To determine if insulin catabolism declines with advancing age.

    Main Methods:

    • Measured steady-state plasma insulin concentrations during exogenous insulin infusion.
    • Suppressed endogenous insulin secretion using epinephrine and propranolol in rats.
    • Analyzed correlations between age and plasma insulin levels in humans during insulin infusion.

    Main Results:

    • Older rats exhibited approximately double the steady-state plasma insulin concentrations compared to younger rats at all infusion rates.
    • Humans showed a significant positive correlation between advancing age and higher steady-state plasma insulin concentrations.
    • These findings held true regardless of the method used to suppress endogenous insulin secretion.

    Conclusions:

    • Insulin catabolism decreases with advancing age.
    • Age-related decline in insulin clearance may have implications for glucose regulation and metabolic health.
    • Further research is warranted to explore the mechanisms behind age-related changes in insulin metabolism.

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