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Keratitis due to Aspergillus flavus successfully treated with thiabendazole
The British Journal of Ophthalmology
|January 1, 1980
Summary
This case report details the successful treatment of Aspergillus flavus keratitis using a 4% thiabendazole suspension. This marks the first documented instance of successful keratomycosis treatment with thiabendazole, offering hope for future therapeutic investigations.
Area of Science:
- Ophthalmology
- Mycology
- Pharmacology
Background:
- Fungal keratitis, specifically Aspergillus flavus keratitis, poses a significant threat to vision.
- Previous treatments for keratomycosis with thiabendazole have yielded poor outcomes, often resulting in enucleation or vision loss.
Observation:
- A single case of Aspergillus flavus keratitis was observed.
- The patient's condition was treated with a 4% suspension of thiabendazole.
Findings:
- Successful resolution of Aspergillus flavus keratitis was achieved with the 4% thiabendazole suspension.
- This represents the first reported case of successful ocular fungal infection treatment using thiabendazole.
Implications:
- Thiabendazole demonstrates potential as a therapeutic agent for keratomycosis due to its ocular tissue penetration, sustained effective concentrations, and broad-spectrum antifungal activity.
- Further investigation into thiabendazole for treating fungal keratitis is warranted.