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Erythema dyschromicum perstans
Journal of the American Academy of Dermatology
|April 1, 1980
Summary
Erythema dyschromicum perstans (EDP) is a skin disorder characterized by a lichenoid reaction, pigment incontinence, and reduced melanocytes. Findings suggest EDP may be identical to lichen planus pigmentosus.
Area of Science:
- Dermatology
- Pathology
- Immunofluorescence
Background:
- Erythema dyschromicum perstans (EDP) was first described in 1957.
- Electron microscopic studies were reported in 1969.
Purpose of the Study:
- To describe five cases of EDP.
- Compare light and electron microscopy, immunofluorescence, and melanocyte counts between normal and affected skin.
- Investigate the relationship between EDP and lichen planus pigmentosus.
Main Methods:
- Light and electron microscopy.
- Direct and indirect immunofluorescence.
- Dopa-positive melanocyte counts.
Main Results:
- EDP presents with a clinically characteristic lichenoid reaction in its active phase.
- The lichenoid reaction causes pigment incontinence, decreased melanocytes, and reduced tyrosinase activity.
- Direct immunofluorescence and fine structural studies show findings similar to lichen planus.
- Patients exhibit low-titer antibodies to extranuclear basal cell components.
Conclusions:
- EDP is a disorder with a lichenoid reaction leading to pigmentary changes.
- Findings support the hypothesis that EDP and lichen planus pigmentosus are the same entity.
- EDP shares immunofluorescence and ultrastructural similarities with lichen planus.