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Metastatic choroidal melanoma.

D H Char

    American Journal of Ophthalmology
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Metastatic choroidal melanoma commonly spreads to the liver, subcutaneous tissue, and bone. Early metastatic screening is crucial for all patients with choroidal melanoma to improve survival outcomes.

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    Area of Science:

    • Ophthalmology
    • Oncology
    • Medical Research

    Background:

    • Choroidal melanoma is a primary ocular tumor with a risk of metastasis.
    • Understanding the metastatic patterns is vital for patient management and prognosis.

    Purpose of the Study:

    • To investigate the metastatic patterns of choroidal melanoma.
    • To determine the common sites and timing of metastasis.
    • To recommend appropriate screening protocols.

    Main Methods:

    • Retrospective analysis of 41 patients with primary choroidal melanoma and subsequent widespread disease.
    • Documentation of metastatic sites, intervals to metastasis, and survival data.

    Main Results:

    • The liver was the most frequent site of metastasis (56%), followed by subcutaneous tissue (36.5%) and bone (7%).

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  • The median interval from enucleation to metastasis was approximately four years.
  • Metastases were occasionally diagnosed concurrently with the primary tumor.

    • Conclusions:

    • Metastatic examination, including serum LDH, serum alkaline phosphatase, chest X-ray, and physical examination, is recommended before and after ocular therapy for all choroidal melanoma patients.
    • Early detection of metastatic choroidal melanoma can significantly impact patient survival, which is typically less than one year after widespread disease onset.