Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in tear flow accompanying aging.

R E Furukawa, K A Polse

    American Journal of Optometry and Physiological Optics
    |February 1, 1978
    PubMed
    Summary

    Tear production decreases with age. A modified slit lamp fluorophotometer measured tear turnover, revealing lower tear secretion rates in older adults, suggesting potential clinical applications for diagnosing tear production anomalies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predicting extended wear complications from overnight corneal swelling.

    Investigative ophthalmology & visual science·2001
    Same author

    The Berkeley Contact Lens Extended Wear Study. Part I : Study design and conduct.

    Ophthalmology·2001
    Same author

    The Berkeley Contact Lens Extended Wear Study. Part II : Clinical results.

    Ophthalmology·2001
    Same author

    The effects of one-hour wear of high-Dk soft contact lenses on corneal pH and epithelial permeability.

    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc·2000
    Same author

    Measurement of post-lens tear thickness.

    Investigative ophthalmology & visual science·1999
    Same author

    Predicting RGP daily wear success.

    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc·1999

    Area of Science:

    • Ophthalmology
    • Physiology
    • Biomedical Engineering

    Background:

    • Tear film dynamics are crucial for ocular surface health.
    • Age-related changes in tear production are not fully understood.
    • Accurate measurement of tear turnover rate is essential for clinical assessment.

    Purpose of the Study:

    • To determine the tear-turnover rate in normal human subjects.
    • To investigate the relationship between age and tear production.
    • To evaluate a modified slit lamp fluorophotometer for clinical use.

    Main Methods:

    • Tear-turnover rate was measured in 68 subjects (age 15-63) using a slit lamp modified as a fluorophotometer.
    • Tear volume and secretion rates were computed from the turnover rate.
    • Subjects were grouped by age (15-39 and 40-63) for comparative analysis.

    Main Results:

    • Mean tear volume was 8.47 microliters and mean tear secretion was 1.78 microliters/min.
    • A significant decrease in tear production was observed with increasing age.
    • Mean tear-flow rate was 1.55 microliters/min (ages 15-39) versus 0.95 microliters/min (ages 40-63).

    Conclusions:

    • Tear production declines with age in normal individuals.
    • The modified slit lamp fluorophotometer is a viable tool for clinical tear assessment.
    • This method may aid in diagnosing and managing tear production disorders.

    Related Experiment Videos