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Thrombotic stroke associated with elevated plasma factor VIII.

K S Kosik, B Furie

    Annals of Neurology
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    A healthy woman experienced severe stroke and clotting due to a fivefold elevated factor VIII level. This suggests a link between high factor VIII and unexplained stroke, recommending factor VIII testing for stroke patients.

    Area of Science:

    • Neurology
    • Hematology
    • Vascular Medicine

    Background:

    • Cerebrovascular accidents (CVAs) and thrombotic events necessitate identifying underlying causes.
    • Disseminated intravascular coagulation (DIC) and hypercoagulable states are critical considerations in thrombotic disease.
    • Middle cerebral artery (MCA) occlusions represent a significant cause of ischemic stroke.

    Observation:

    • A 43-year-old woman presented with bilateral MCA occlusions, thrombocytopenia, and splenic artery thrombi.
    • Extensive diagnostic workup failed to reveal a cause for the thrombotic diathesis.
    • A fivefold elevation in factor VIII (FVIII) levels was the sole significant laboratory abnormality detected.

    Findings:

    • The patient's thrombotic event, including MCA occlusion and thrombocytopenia, correlated with markedly elevated FVIII levels.

    Related Experiment Videos

  • A potential etiological link between high FVIII activity and the occurrence of cerebral and systemic arterial thrombosis is proposed.
  • This case highlights a possible association between hyperfactorability and ischemic stroke in the absence of other identifiable causes.

    • Implications:

    • Elevated FVIII levels may represent a risk factor for ischemic stroke and other thrombotic events.
    • Assaying FVIII levels in patients presenting with stroke of unknown etiology is recommended.
    • Further research into the role of FVIII in thrombogenesis and its clinical significance in cerebrovascular disease is warranted.