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Hypoxic ventilatory response in the newborn monkey.

D E Woodrum, T A Standaert, D E Mayock

    Pediatric Research
    |April 1, 1981
    PubMed
    Summary
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    Newborn monkeys show a temporary increase in breathing during low oxygen, which becomes sustained over time. This infant primate model mimics human infant responses to hypoxia.

    Area of Science:

    • Neonatal Physiology
    • Respiratory Control
    • Comparative Medicine

    Background:

    • The hypoxic ventilatory response (HVR) is critical for survival.
    • Understanding HVR maturation in infants is crucial for respiratory health.
    • Newborn primates offer a relevant model for studying human infant respiratory development.

    Purpose of the Study:

    • To characterize the hypoxic ventilatory response in newborn Macaca nemestrina.
    • To investigate the postnatal maturation of respiratory control in infant primates.
    • To establish the infant monkey as a model for human infant HVR studies.

    Main Methods:

    • Twelve unanesthetized newborn monkeys (Macaca nemestrina) were studied.
    • Ventilation and blood gases were measured during normoxia and hypoxia (FiO2 0.12-0.14).

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  • Data were collected during quiet sleep at 2, 7, and 21 days postnatal.

    • Main Results:

    • A transient hyperventilatory response to hypoxia was observed on day 2.
    • Ventilation increased significantly (15-28%) within 1 minute of hypoxia.
    • The response matured into sustained hyperventilation over three weeks, with periodic breathing noted.

    Conclusions:

    • Infant Macaca nemestrina exhibit a biphasic HVR that matures into sustained hyperventilation.
    • The infant primate HVR closely resembles that of human infants.
    • This species serves as a valuable model for studying the maturation of respiratory control systems.