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Related Experiment Videos

Searching for the infertile man with hyperprolactinemia.

T B Hargreave, J D Richmond, J Liakatas

    Fertility and Sterility
    |November 1, 1981
    PubMed
    Summary

    Routine prolactin measurement is not useful for investigating male infertility. Most prolactin levels remained within normal ranges, indicating no significant hyperprolactinemia in infertile men.

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    Introductory remarks.

    Bulletin of the New York Academy of Medicine·2009

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Men's Health

    Background:

    • Hyperprolactinemia, elevated prolactin levels, can impact male reproductive function.
    • Investigating male infertility often involves assessing various hormonal factors.
    • The role of routine prolactin testing in male infertility workup requires clarification.

    Purpose of the Study:

    • To evaluate the clinical utility of routine prolactin measurement in the diagnostic workup of male infertility.
    • To determine if prolactin levels differ significantly between men with primary infertility, secondary infertility, and fertile controls.

    Main Methods:

    • Comparative analysis of serum prolactin levels.
    • Inclusion of three groups: primary infertility, secondary infertility, and fertile controls.
    • Statistical evaluation of prolactin level variations across groups.

    Main Results:

    • A statistically significant, yet slight, elevation in prolactin levels was observed in men with primary infertility compared to secondary infertility and fertile controls.
    • The majority of prolactin measurements in all groups fell within the standard laboratory normal range.
    • No clinically significant cases of hyperprolactinemia were identified in the study population.

    Conclusions:

    • Routine prolactin estimation is not routinely justified for investigating male infertility.
    • Prolactin measurement should be reserved for cases with specific clinical indications such as impotence, dialysis, or a history of pituitary disease.

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