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Poly (ADP-ribosylation) in N, N-diethylnitrosamine-treated mice
The International Journal of Biochemistry
|January 1, 1982
Abstract:
1. Liver nuclei isolated from male mice treated with the carcinogen N, N-diethylnitrosamine were examined for the homopolymer poly(adenosine diphosphate ribose) and for the activity of the conjugate polymerase. 2. At all levels of the carcinogen tested, a concomitant increase in both poly(adenosine diphosphate ribose) content and activity of the enzyme were found. 3. Both responses were transitory and dose dependent.