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[Tissue chemoreceptors].

V A Lebedeva, L V Filippova, T N Bratus'

    Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
    |February 1, 1982
    PubMed
    Summary

    Acidosis in small intestine tissue, induced by acids like lactic and carbonic, increases nerve signals and blood pressure in cats. Tissue chemoreceptors are sensitive to metabolic acidosis, influencing blood pressure and respiration.

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    Area of Science:

    • Physiology
    • Neuroscience
    • Gastroenterology

    Context:

    • Acidosis, a disruption of acid-base balance (AAB), can significantly impact physiological functions.
    • Understanding the role of tissue chemoreceptors in sensing metabolic changes is crucial for physiological regulation.

    Purpose:

    • To investigate the effects of induced acidosis in small intestine tissue on splanchnic nerve activity and arterial pressure.
    • To compare the sensitivity of tissue chemoreceptors to metabolic versus respiratory acidosis.
    • To explore the role of tissue chemoreceptors in the reflex control of respiration.

    Summary:

    • Intraarterial acid administration or acidosis induction in feline small intestine tissue elevated splanchnic nerve impulsation and arterial pressure.
    • Tissue receptors demonstrated higher sensitivity to metabolic acidosis than respiratory acidosis, correlating with intratissue pH changes.
    • Skeletal muscle chemoreceptors showed lower sensitivity, but responses occurred within normal acid-base balance parameter ranges.
    • Changes in ventilation volume suggested a role for tissue chemoreceptors in respiratory reflex control.
    • Receptor sensitivity to carbonic and lactic acids supports the concept of tissue chemoreceptors as key sensors of tissue metabolism intensity.

    Impact:

    • Provides evidence for tissue chemoreceptors' role in sensing metabolic byproducts like lactic and carbonic acids.
    • Highlights the differential sensitivity of chemoreceptors to metabolic versus respiratory acidosis.
    • Suggests a role for tissue chemoreceptors in the reflex regulation of both arterial pressure and respiration.

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