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Related Experiment Videos

Non-volatile N-nitroso compounds in human feces.

A J Varghese, P C Land, R Furrer

    IARC Scientific Publications
    |January 1, 1978
    PubMed
    Summary

    A bacterial mutagen was found in human feces, possibly a nitroso compound. Dietary ascorbic acid (vitamin C) supplementation significantly reduced levels of both mutagens and nitroso compounds.

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    Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde.

    Chemico-biological interactions·2011

    Area of Science:

    • Microbiology
    • Toxicology
    • Nutritional Science

    Background:

    • Bacterial mutagens have been detected in human fecal matter.
    • Western diets are associated with potential increases in fecal mutagens.

    Purpose of the Study:

    • To identify and characterize bacterial mutagens in human feces.
    • To investigate the potential role of nitroso compounds as fecal mutagens.
    • To assess the impact of ascorbic acid on fecal mutagen and nitroso compound levels.

    Main Methods:

    • Ether extraction of freeze-dried human feces.
    • Detection of bacterial mutagenic activity.
    • Chemical analysis to identify nitroso compounds.

    Main Results:

    • A bacterial mutagen was identified in ether extracts of human feces from individuals on a Western diet.
    • Evidence suggests the mutagen is a nitroso compound.
    • Ascorbic acid supplementation in the diet led to a reduction in both mutagen and nitroso compound levels in feces.

    Conclusions:

    • Nitroso compounds are likely present in human feces and contribute to mutagenicity.
    • Dietary intake of ascorbic acid can mitigate the levels of these harmful compounds.

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