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Brain imaging with emission computed tomography and radiolabeled amines.
Investigative Radiology
|May 1, 1982
Summary
Measuring regional cerebral blood flow is now accessible using I-123 iodoamphetamine and standard SPECT imaging. This technique aids in assessing neurologic diseases like stroke and epilepsy.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Noninvasive regional cerebral blood flow measurement was previously limited by specialized, costly equipment.
- Radiolabeled lipophilic amines are extracted by the brain proportionally to blood flow.
Purpose of the Study:
- To demonstrate that I-123 iodoamphetamine imaging can be used with standard SPECT instrumentation for cerebral blood flow assessment.
- To highlight the utility of this method for detecting perfusion changes in neurologic conditions.
Main Methods:
- Utilized I-123 iodoamphetamine, a radiolabeled amine.
- Employed standard single photon emission computed tomography (SPECT) instrumentation.
- Obtained scintigraphic maps of regional cerebral blood flow.
Main Results:
- Demonstrated the feasibility of obtaining regional cerebral blood flow maps using commercially available SPECT scanners.
- Showcased the ability of I-123 iodoamphetamine imaging to detect altered brain perfusion.
Conclusions:
- I-123 iodoamphetamine SPECT imaging provides a more accessible method for measuring regional cerebral blood flow.
- This technique offers valuable physiological data complementing anatomical imaging in diagnosing neurologic diseases such as cerebral infarction and epilepsy.