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Related Experiment Videos

Calcium binding by radiopaque media.

T W Morris, L G Sahler, H W Fischer

    Investigative Radiology
    |September 1, 1982
    PubMed
    Summary

    Contrast media containing edetate and citrate significantly bind ionic calcium. Sodium diatrizoate also binds calcium, while nonionic agents like iopamidol do not affect ionic calcium levels.

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    Area of Science:

    • Radiology
    • Biochemistry
    • Medical Imaging

    Background:

    • Ionic calcium plays a crucial role in physiological processes.
    • Contrast media are widely used in medical imaging.
    • The interaction between contrast media and ionic calcium is not fully understood.

    Purpose of the Study:

    • To quantify the binding of ionic calcium by different contrast media formulations.
    • To compare calcium binding by contrast media containing disodium edetate and trisodium citrate versus those with calcium disodium edetate alone.
    • To investigate the role of specific components like the diatrizoate anion in calcium binding.

    Main Methods:

    • Utilized an ion-selective electrode to measure ionic calcium concentrations.
    • Tested contrast media at various ionic strengths (.08, .16, and .80 molal).
    • Analyzed solutions containing Renografin 76 (Hypaque 76), sodium diatrizoate, and iopamidol.

    Main Results:

    • Significant binding of ionic calcium was observed with contrast media containing disodium edetate and trisodium citrate.
    • Sodium diatrizoate, particularly as calcium chloride diatrizoate, showed significant calcium binding.
    • Renografin 76 demonstrated greater calcium binding than Hypaque 76, with the diatrizoate anion contributing to 60% of the reduction.
    • The nonionic contrast agent iopamidol did not decrease ionic calcium levels.

    Conclusions:

    • Both the diatrizoate anion and additives like edetate and citrate significantly reduce ionic calcium.
    • Contrast media composition critically influences ionic calcium levels.
    • Understanding these interactions is vital for interpreting imaging studies and patient safety.

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