Effect of metoclopramide and lisuride on hypophyseal and gonadal function in men

The effects of chronic treatment over 7 weeks with metoclopramide and lisuride alone as well as the combination of both drugs were studied on basal and TRH/LHRH stimulated serum PRL, testosterone, LH, FSH, GH, and TSH concentrations. The study was conducted under double-blind placebo-controlled conditions and included twenty-four healthy male volunteers. In addition, repeated seminal fluid analyses were performed before, during and after treatment. While the known PRL-stimulatory effect of metoclopramide and the PRL-lowering effect of lisuride could be confirmed, we were unable to demonstrate any substance-related effects on the other hypophyseal or gonadal hormones. In contrast to previously published data no adverse effects of metoclopramide on sperm analysis could be demonstrated.