Differential toxicity of methylglyoxal-bis [guanylhydrazone]

The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal-bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine. We have looked at the relative MGBG toxicity of two different murine melanoma tumour cell lines (Harding-Passey and Cloudman) and normal murine fibroblasts, and found wide variation with no correlation in sensitivity to MGBG between tumour and normal cells. High sensitivity to MGBG may be associated with high transport across the cell membrane.