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Diatrizoate CT distribution kinetics: a study of human tissue characterization
Journal of Computer Assisted Tomography
|April 1, 1983
Summary
This study introduces Diatrizoate Distribution Volume (DDV) as a measure of contrast material in tissues. CT-DDV shows potential for identifying diffuse organ pathology in humans.
Area of Science:
- Radiology
- Medical Imaging
- Pharmacokinetics
Background:
- Diatrizoate distribution volume (DDV) quantifies contrast agent distribution in tissues.
- Computed tomography (CT) is a key imaging modality for assessing tissue characteristics.
Purpose of the Study:
- To compile Diatrizoate Distribution Volume (DDV) and enhancement data from CT scans of normal adult human tissues.
- To evaluate the utility of CT-derived DDV as an indicator of diffuse organ pathology.
Main Methods:
- Collected CT data and calculated DDV and enhancement values for normal tissues (liver, spleen, muscle, fat, renal cortex) after intravenous diatrizoate administration.
- Compared DDV and enhancement in normal tissues with abnormal tissues (cirrhotic liver, metastatic colon carcinoma, renal malignant lymphoma).
Main Results:
- Generated time-DDV and time-enhancement curves for normal human tissues.
- Observed variations in DDV and enhancement patterns across different normal tissues.
- Demonstrated differences in DDV and enhancement between normal and abnormal tissue samples.
Conclusions:
- CT-derived Diatrizoate Distribution Volume (DDV) shows promise as a quantitative biomarker.
- DDV may serve as a reliable indicator for detecting and characterizing diffuse organ pathologies.