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Nutrition and immune responses.

R K Chandra

    Canadian Journal of Physiology and Pharmacology
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Nutritional deficiencies impair immune responses, increasing infection susceptibility. Diet significantly impacts host resistance to disease, affecting immunity functions in both undernutrition and obesity.

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    Area of Science:

    • Nutrition and Immunology
    • Infectious Disease Epidemiology

    Background:

    • Clinical and epidemiologic data suggest a link between nutrition and infection.
    • Malnutrition impairs immune responses, heightening susceptibility to infections.
    • Obesity is also linked to compromised cellular immunity.

    Purpose of the Study:

    • To review the impact of nutritional status on immune function and host resistance.
    • To highlight the role of specific nutrient deficiencies in immune depression.
    • To discuss metabolic and hormonal changes associated with malnutrition and immunity.

    Main Methods:

    • Review of clinical and epidemiologic data.
    • Analysis of studies on nutrient deficiencies and immune function.
    • Examination of research on obesity and immune responses.

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    Main Results:

    • Protein-energy undernutrition and deficiencies (e.g., iron, zinc, pyridoxine) depress cell-mediated immunity, complement system, phagocyte activity, and antibody responses.
    • Metabolic, hormonal, and lymphocyte subpopulation alterations are observed in malnutrition.
    • Obesity is associated with impaired cellular immune functions.

    Conclusions:

    • Nutritional status is critical for immune function and host defense against infection.
    • Dietary factors play a pivotal role in modulating resistance to disease.
    • Addressing nutritional deficiencies is essential for improving immunity.