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Tetracycline toxicity presenting as generalized vasculitis.

J R Kelly, K Andolsek

    Southern Medical Journal
    |August 1, 1978
    PubMed
    Summary
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    This case report details a rare instance of tetracycline toxicity manifesting as multisystem involvement and a positive antinuclear antibody (ANA) test. Symptoms resolved completely after discontinuing the antibiotic.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Internal Medicine

    Background:

    • Tetracyclines are broad-spectrum antibiotics with a known side effect profile.
    • Multisystemic adverse drug reactions are uncommon but can be severe.
    • Antinuclear antibody (ANA) positivity can be associated with drug-induced lupus.

    Observation:

    • A patient presented with symptoms suggestive of multisystemic disease.
    • The patient had a history of tetracycline use.
    • Laboratory tests revealed a positive ANA test.

    Findings:

    • The clinical presentation and laboratory findings were consistent with an adverse reaction to tetracycline.
    • All observed toxic manifestations, including ANA positivity, resolved after drug cessation.

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    Implications:

    • This case highlights an infrequently reported manifestation of tetracycline toxicity.
    • Physicians should consider drug-induced toxicity in patients with unexplained multisystemic symptoms.
    • Early recognition and drug withdrawal are crucial for complete recovery from tetracycline-induced adverse effects.