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Synthetic materials for platelet quality control.

J A Lott, R K Hartzell, J Longberry

    The American Journal of Medical Technology
    |January 1, 1983
    PubMed
    Summary
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    New synthetic platelet controls offer improved stability and accurate size distribution for reliable automated platelet counting. These novel materials address limitations of current methods, enhancing quality control in hematology laboratories.

    Area of Science:

    • Hematology
    • Clinical Chemistry
    • Biomaterials Science

    Background:

    • Current quality control for automated platelet counting lacks ideal standards.
    • Human or animal platelet controls exhibit limited stability.
    • Existing synthetic controls do not accurately replicate fresh platelet size distribution.

    Purpose of the Study:

    • To develop novel, wholly synthetic platelet control materials.
    • To ensure synthetic platelet controls possess a size distribution similar to fresh human platelets.
    • To create a dispersing medium mimicking plasma viscosity and surface tension.

    Main Methods:

    • Development of two types of synthetic platelet control materials.
    • Type 1: Dilutions for direct use on instruments like the Coulter ZBI.

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  • Type 2: Whole blood-like product for instruments such as the Coulter Model S-Plus.

    • Main Results:

    • Type 1 dilutions yielded counts of approximately 50,000 and 200,000/microL on the Coulter ZBI.
    • Type 1 controls demonstrated stability for at least 30 days at various temperatures (-20C, 4C, 37C) and 8 months at 25C.
    • Type 2 product yielded counts of approximately 200,000/microL and was stable for at least 120 days across tested temperatures.
    • Freezing Type 2 product resulted in temporary aggregates that dispersed upon thawing and standing.

    Conclusions:

    • Wholly synthetic platelet control materials with appropriate particle size distribution and dispersing medium properties have been developed.
    • These novel controls demonstrate excellent stability, addressing key limitations of current platelet counting quality control methods.
    • The synthetic materials offer a reliable and stable alternative for ensuring accuracy in automated platelet enumeration.