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Linear growth patterns in patients with cleft lip or palate or both
American Journal of Diseases of Children (1960)
|February 1, 1983
Summary
Children with isolated cleft palate often experience decreasing height percentiles with age. Patients with cleft lip with or without cleft palate exhibit a distinct bimodal height distribution, separating into short and tall groups.
Area of Science:
- Pediatric endocrinology
- Genetics
- Craniofacial anomalies
Background:
- Growth patterns in children with cleft palate are not fully understood.
- Previous studies have not consistently characterized height trajectories in isolated cleft palate (ICP) and cleft lip with or without cleft palate (CLP).
Purpose of the Study:
- To investigate and compare longitudinal height development in patients with ICP versus CLP.
- To identify distinct growth patterns associated with different types of clefting.
Main Methods:
- Sequential height measurements were collected over an 11-year period.
- Height percentiles were analyzed in relation to age for both ICP and CLP patient cohorts.
- Parental height data was used to assess genetic contributions to stature.
Main Results:
- Patients with ICP showed a trend of decreasing height percentiles with age, with 26% falling below the fifth percentile after age 8.
- Patients with CLP displayed a bimodal height distribution after age 4, with 65% in a short group and 35% in a tall group.
- Parental heights were typically normal, suggesting altered polygenic inheritance in ICP and an unexpected distribution in CLP.
Conclusions:
- ICP is associated with impaired linear growth and potential growth deceleration.
- CLP exhibits a unique bimodal growth pattern not directly explained by parental stature.
- Further research is needed to understand the genetic and environmental factors influencing these distinct growth trajectories.