[Effect of cholinolytics on thermoregulation processes in hypothermia]

Acute experiments on rats were made to study variations of the hypothermia development ratio (HDR) under the effect of cholinolytics at mild, medium and deep hypothermia stages, corresponding with 33,26 and 19 degrees C of rectal temperature. Amizyl (20 mg/kg) and spasmolytin (10 mg/kg) were used as central cholinolytics, whereas metacin (20 mg/kg), isoverin (10 mg/kg) and diplacin (8 mg/kg) as peripheral ones. The character of the action of central cholinolytics of the HDR is largely determined by the hypothermia stage, while that of peripheral ones by the type and localization of cholinoreceptors under blockade.