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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

229
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
229
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

245
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
245
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

259
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
259
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

237
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
237
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

203
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
203
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

193
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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[Regression of hypertrophy of the left ventricle in hypertensive subjects treated with captopril].

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Related Experiment Video

Updated: Jan 26, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
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[Cardiological methods in geriatrics].

G Forin

    Minerva Medica
    |May 19, 1983
    PubMed
    Summary

    This review covers cardiological methods for diagnosing heart disease in the elderly, focusing on senile myocardiopathy and bundle-branch blocks. It details non-invasive and invasive techniques, guiding geriatric specialists in patient management.

    Area of Science:

    • Cardiology
    • Geriatrics

    Background:

    • Geriatric cardiology requires specialized knowledge of age-related cardiac changes.
    • Elderly patients present unique challenges in cardiac examination and diagnosis.

    Purpose of the Study:

    • To review cardiological methods for examining and diagnosing heart diseases in the elderly.
    • To highlight recent literature and research on geriatric cardiac conditions.

    Main Methods:

    • Review of cardiological examination techniques applicable to the elderly.
    • Discussion of non-invasive diagnostic modalities (indications, limits).
    • Consideration of invasive methods like His bundle study, cardiac catheterization, and angiocardiography in selected cases.

    Main Results:

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  • Detailed explanation of non-invasive examination indications, modalities, meaning, and limits.
  • Emphasis on specific conditions: senile myocardiopathy and bundle-branch blocks in the elderly.
  • Evaluation of invasive procedures for therapeutic and rehabilitative management.

    • Conclusions:

    • Geriatric specialists need comprehensive understanding of cardiac diagnostics in the elderly.
    • Non-invasive methods are crucial, with invasive procedures reserved for specific management decisions.
    • Interventions aim to prolong or improve quality of life, even in advanced age.