[Comparison of the changes in mitotic activity and in serotonin concentration in regenerating liver]

Mobilization of serotonin in intestine and its accumulation in liver and spleen tissues were observed at the initial periods after partial hepatectomy. Later on, content of serotonin was gradually decreased in liver tissue, however, its dynamics exhibited a phasic pattern--the minimal level of the amine coincided in time with the maximal mitotic activity. A negative correlation was found between the content of endogenous serotonin and mitotic activity. Possible role of endogenous serotonin in proliferating processes is discussed.