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Indomethacin- and Moduretic--induced hyperkalemia.

R Mor, S Pitlik, J B Rosenfeld

    Israel Journal of Medical Sciences
    |June 1, 1983
    PubMed
    Summary

    Combining indomethacin and Moduretic (amiloride HCl, hydrochlorothiazide) can cause severe hyperkalemia. This drug interaction, not seen with individual drugs, suggests a potassium imbalance mechanism.

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    Area of Science:

    • Pharmacology
    • Nephrology
    • Internal Medicine

    Background:

    • Drug interactions can lead to unexpected adverse effects.
    • Hyperkalemia is a serious condition requiring careful management.

    Observation:

    • A 78-year-old patient developed severe hyperkalemia twice.
    • The hyperkalemia occurred only when indomethacin and Moduretic were administered simultaneously.

    Findings:

    • Neither indomethacin nor Moduretic caused significant potassium level changes when given alone.
    • Laboratory data suggest altered internal potassium balance as the primary cause of this drug-induced hyperkalemia.

    Implications:

    • Clinicians should be aware of the potential for severe hyperkalemia when prescribing this drug combination.
    • Further research into the specific mechanism of potassium imbalance is warranted.

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