Biliary excretion of bromosulfthalein in rabbit

The effect of bromosulfthalein (BSP) infusions at different doses on bile secretion was investigated in anaesthetized rabbits. The patterns of biliary excretion were found to be similar to other mammals, maximal biliary excretion being achieved by an infusion of 0.50 mg X kg-1 body weight X min-1. Bromosulfthalein administered at low doses under the maximum hepatic transport capacity resulted in a clear increase of bile flow which was mainly due to an osmotic mechanism. Supramaximal doses produced no effect on bile flow.