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[Ultrastructure of activation of connective and lymphoid tissue cells during experimental infectious-allergic
As a result of multiple and long-term antigenic stimulation with streptococcal products in experimental infectious-allergic carditis (EIAC) in rabbits there occurs functional activation of young connective-tissue cells of the cardiac valve, endothelial and perithelial cells of myocardium vessels and cells of the lymphoid tissue. Enhanced secretion of tropocollagen is common for mesenchymal heart cells in EIAC. At that, the most marked fibrillogenesis is observed in the cardiac valve in which tropocollagen is aggregated into mature fibrillae. Fibrillogenesis is less marked around myocardial pericytes, and formation of thinner, incompletely formed pre-collagen (FLS) fibrillae is predominant. In EIAC, in lymphoid organs plasmatization of B-lymphocytes and increased immunoglobulin formation in plasma cells are observed which is most marked in cisterns of a rough ergastoplasmic reticulum of immature cells.
As a result of multiple and long-term antigenic stimulation with streptococcal products in experimental infectious-allergic carditis (EIAC) in rabbits there occurs functional activation of young connective-tissue cells of the cardiac valve, endothelial and perithelial cells of myocardium vessels and cells of the lymphoid tissue. Enhanced secretion of tropocollagen is common for mesenchymal heart cells in EIAC. At that, the most marked fibrillogenesis is observed in the cardiac valve in which tropocollagen is aggregated into mature fibrillae. Fibrillogenesis is less marked around myocardial pericytes, and formation of thinner, incompletely formed pre-collagen (FLS) fibrillae is predominant. In EIAC, in lymphoid organs plasmatization of B-lymphocytes and increased immunoglobulin formation in plasma cells are observed which is most marked in cisterns of a rough ergastoplasmic reticulum of immature cells.