Related Experiment Video

Updated: Jul 16, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

Cis-trans test shows a functional relationship between non-allelic lethal mutations in the T/t-complex

H S Shin, P McCormick, K Artzt

    Cell
    |July 1, 1983
    PubMed
    Summary

    Recessive lethal mutations in mouse T/t-complex exhibit defective genetic complementation. The cis-trans test revealed these mutations form a functional unit, suggesting a role for DNA plasticity in their genetic relationship.

    More Related Videos

    High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii10:51

    High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii

    Published on: December 5, 2016

    Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis06:33

    Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

    Published on: June 9, 2018

    Related Concept Videos

    Test Cross01:39

    Test Cross

    Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
    Complementation Tests00:49

    Complementation Tests

    A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
    Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
    Comparing Experimental Results: Student's t-Test01:09

    Comparing Experimental Results: Student's t-Test

    The t-test is a statistical method used to compare the sample mean with a population mean or compare two means from two data sets. The test statistic is calculated from the standard deviation, mean, and number of measurements in the data set at a selected confidence interval and then compared to a table of critical values at this confidence level. If the test statistic is smaller than the critical value, the null hypothesis is accepted. In this case, we state that the difference between the...
    Tissue Transplantation01:24

    Tissue Transplantation

    Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
    The Biology of Tissue Transplantation
    The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
    Toxicity Testing in Animals01:23

    Toxicity Testing in Animals

    Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
    Microsoft Excel: Student's t-Test01:25

    Microsoft Excel: Student's t-Test

    Student's t-test in Microsoft Excel is a statistical method used to compare the means of two groups to determine if they are significantly different from each other. It's commonly used to evaluate hypotheses, such as testing whether a treatment has an effect compared to a control group. Excel provides built-in functions to perform t-tests, making it accessible for users needing to conduct basic statistical analysis.
    To conduct a t-test in Excel, use the T.TEST function or the "Data Analysis...