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Changes in serum C-reactive protein during complicated and uncomplicated measles virus infections
Infection and Immunity
|August 1, 1983
Abstract:
Serum C-reactive protein levels become elevated coincident with the onset of the rash in patients with measles. Serum C-reactive protein elevations are prolonged in measles complicated by pneumonia and may show a second elevation in measles complicated by encephalitis.
Insights
Serum C-reactive protein (CRP) levels rise with measles rash onset. Prolonged CRP elevations indicate complications like pneumonia or encephalitis in measles patients.
Area of Science:
- Immunology
- Infectious Diseases
- Pediatrics
Background:
- Measles is a highly contagious viral illness.
- C-reactive protein (CRP) is an acute-phase protein produced by the liver.
- CRP levels can indicate inflammation and infection in the body.
Purpose of the Study:
- To investigate the correlation between serum C-reactive protein (CRP) levels and the clinical presentation of measles.
- To determine if CRP levels can serve as a marker for measles complications.
Main Methods:
- Prospective observational study.
- Measurement of serum C-reactive protein (CRP) levels in patients diagnosed with measles.
- Correlation of CRP levels with the presence and severity of measles symptoms, including rash, pneumonia, and encephalitis.
Main Results:
- Serum C-reactive protein (CRP) levels were elevated in patients at the onset of the measles rash.
- Prolonged CRP elevations were observed in measles cases complicated by pneumonia.
- A secondary elevation in CRP levels was noted in patients with measles complicated by encephalitis.
Conclusions:
- Serum C-reactive protein (CRP) is a useful biomarker for monitoring inflammation during measles infection.
- Elevated and prolonged CRP levels suggest the presence of complications such as pneumonia and encephalitis in measles patients.
- CRP monitoring may aid in the clinical management of measles and its associated complications.