Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential changes in oligoclonal patterns during the course of multiple sclerosis.

E J Thompson, P Kaufmann, P Rudge

    Journal of Neurology, Neurosurgery, and Psychiatry
    |June 1, 1983
    PubMed
    Summary

    Multiple sclerosis patients often show abnormal spinal fluid immunoglobulin patterns. Longitudinal studies reveal changes in these oligoclonal bands, potentially impacting disease understanding.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

    Journal of neuroimmunology·2010
    Same author

    Modeling and observations of phase-mask trapezoidal profiles with grating-fiber image reproduction.

    Applied optics·2008
    Same author

    Formation of phase gratings on the end of gradient-index lenses with ultraviolet ablation at 193 nm.

    Applied optics·2008
    Same author

    Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients.

    European journal of neurology·2006
    Same author

    Seroprevalence of herpes simplex virus type 2 in multiple sclerosis.

    Acta neurologica Scandinavica·2006
    Same author

    CSF neurofilament levels: a potential prognostic marker in Guillain-Barré syndrome.

    Neurology·2006

    Area of Science:

    • Neurology
    • Immunology
    • Clinical Chemistry

    Background:

    • Multiple sclerosis (MS) is characterized by immune system dysfunction.
    • Abnormalities in cerebrospinal fluid (CSF) immunoglobulins are common in MS patients.
    • Electrophoresis reveals characteristic patterns, termed oligoclonal bands, in the gamma globulin region.

    Purpose of the Study:

    • To investigate longitudinal changes in CSF immunoglobulin patterns in multiple sclerosis patients.
    • To explore the significance of these changes for understanding MS pathogenesis.
    • To discuss the role of specific immunoglobulin isotypes (IgM, IgA) in interpreting these findings.

    Main Methods:

    • Analysis of cerebrospinal fluid (CSF) samples.
    • Immunoglobulin electrophoresis to detect protein band patterns.

    Related Experiment Videos

  • Longitudinal patient monitoring to observe changes over time.

    • Main Results:

    • The majority of multiple sclerosis patients exhibit abnormal spinal fluid immunoglobulin patterns.
    • Changes in the electrophoretic banding patterns were observed in some patients during longitudinal studies.
    • These alterations are described as patterns of restricted heterogeneity or oligoclonal patterns.

    Conclusions:

    • Longitudinal changes in CSF oligoclonal bands may offer insights into the pathogenesis of multiple sclerosis.
    • Methodological considerations are crucial for accurate interpretation of immunoglobulin patterns.
    • The involvement of IgM and IgA may be significant for a comprehensive understanding of these observations in MS.