[Oxygen status of transplantable murine tumors and its change during radiotherapy]

The degree of oxygenation in sarcoma 37, Lewis' carcinoma and melanoma B-16 of mice has been shown to depend on a tumor type (the most marked degree in sarcoma 37), it decreases from the periphery and with tumor growth. In single and fractionated irradiation the oxygen tension increases considerably in large size tumors and in the central zones of small size tumors. In melanoma B-16 reoxygenation is insignificant. It is assumed that the oxygen status plays an important role in the radiation response of large size tumors only.