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Post-heparin plasma lipolytic activity in acute hepatitis
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
|May 1, 1978
Summary
Post-heparin plasma lipolytic activity (PHLA) was significantly reduced in patients with acute viral hepatitis, showing a slower recovery than standard liver function tests. PHLA may serve as a sensitive new indicator of liver function.
Area of Science:
- Hepatology
- Biochemistry
- Clinical Chemistry
Background:
- Acute viral hepatitis can impair liver function.
- Lipolytic activity in plasma is influenced by liver function.
Purpose of the Study:
- To investigate post-heparin plasma lipolytic activity (PHLA) in patients with acute viral hepatitis.
- To assess the potential of PHLA as a sensitive marker for liver function during hepatitis.
Main Methods:
- PHLA was measured in 21 patients diagnosed with acute viral hepatitis.
- PHLA levels were compared to those of control subjects.
- Correlation between PHLA values and serum triglycerides was analyzed.
Main Results:
- PHLA was significantly reduced in all hepatitis patients (p < 0.0005), averaging 32% of control levels.
- An inverse correlation was observed between PHLA and serum triglycerides (p < 0.05).
- PHLA normalization during recovery was notably slower than conventional liver function tests.
Conclusions:
- PHLA is significantly impaired in acute viral hepatitis.
- PHLA shows a slower recovery pattern compared to standard liver function tests.
- PHLA measurement could be a novel and sensitive diagnostic tool for assessing liver function in hepatitis.