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Left ventricular function at rest and during exercise in coronary insufficiency--a simultaneous evaluation by means

J A Dahlström, B Lilja, O Ohlsson

    Clinical Physiology (Oxford, England)
    |December 1, 1982
    PubMed

    Insights

    Effort angina causes left ventricular dysfunction, characterized by elevated filling pressures and reduced ejection fraction during exercise. Both heart catheterization and radionuclide angiocardiography effectively detect these changes.

    Area of Science:

    • Cardiology
    • Cardiovascular Physiology

    Background:

    • Effort angina is a common condition associated with myocardial ischemia.
    • Assessing left ventricular (LV) function during exercise is crucial for understanding disease severity.

    Purpose of the Study:

    • To evaluate left ventricular function during exercise in patients with effort angina.
    • To compare the diagnostic capabilities of heart catheterization and radionuclide angiocardiography in detecting exercise-induced LV dysfunction.

    Main Methods:

    • Simultaneous assessment of LV function using heart catheterization and equilibrium radionuclide angiocardiography (ERNA).
    • Measurements were taken at rest and during supine exercise in ten patients with effort angina.

    Main Results:

    • Patients developed angina and LV dysfunction during exercise, with high LV filling pressures (31 +/- 2 mm Hg) and decreased ejection fraction (11 +/- 1% units).
    • Significant increase in LV end-systolic volume (43 +/- 7%) but not end-diastolic volume (13 +/- 7%).
    • ERNA detected LV dysfunction as frequently as heart catheterization.

    Conclusions:

    • Exercise-induced left ventricular dysfunction is a key feature of effort angina.
    • Both heart catheterization and ERNA are valuable tools for assessing LV function in effort angina.
    • The discordance between LV filling pressure and volume changes warrants further investigation.

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